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Best South America Cruises

Find the Best South America Cruises for you. Easily compare prices and find out when to book your dream vacation to South America with our cruise search.

Very good price

Compared to other cruises

17 Night South America
Oosterdam
4.0 "Good"

PORTS

Fort Lauderdale; George Town, Cayman Islands; Fuerte Amador, Pan... San Antonio, Ibiza, Balearic Islands

SAIL DATE:   Nov 17, 2025   -   Dec 04, 2025

Interior

$1749 $102/night
Price Curve

Oceanview

$1799 $105/night
Price Curve

Balcony

$2349 $138/night
Price Curve

Suite

$3149 $185/night
Price Curve

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Very good price

Compared to other cruises

7 Night South America
MSC Lirica
2.9 "Nice"

PORTS

Piraeus; Izmir (Ephesus) Turkey; Istanbul; Corfu; Bari, Italy; Piraeus

SAIL DATE:   Jan 19, 2026   -   Jan 26, 2026

Interior

$569 $81/night
Price Curve

Oceanview

$699 $99/night
Price Curve

Balcony

$989 $141/night
Price Curve

Suite

$1189 $169/night
Price Curve

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Very good price

Compared to other cruises

7 Night South America
MSC Lirica
2.9 "Nice"

PORTS

Piraeus; Izmir (Ephesus) Turkey; Istanbul; Corfu; Bari, Italy; Piraeus

SAIL DATE:   Jan 12, 2026   -   Jan 19, 2026

Interior

$617 $88/night
Price Curve

Oceanview

$757 $108/night
Price Curve

Balcony

$1047 $149/night
Price Curve

Suite

$1247 $178/night
Price Curve

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Very good price

Compared to other cruises

7 Night South America
MSC Lirica
2.9 "Nice"

PORTS

Piraeus; Izmir (Ephesus) Turkey; Istanbul; Corfu; Bari, Italy; Piraeus

SAIL DATE:   Jan 05, 2026   -   Jan 12, 2026

Interior

$619 $88/night
Price Curve

Oceanview

$749 $107/night
Price Curve

Balcony

$1049 $149/night
Price Curve

Suite

$1239 $177/night
Price Curve

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-5%

17 Night South America
Oosterdam
4.0 "Good"

PORTS

San Antonio, Ibiza, Balearic Islands; Coquimbo (La Serena), Chile; General San Martin... Fort Lauderdale

SAIL DATE:   Mar 22, 2026   -   Apr 08, 2026

Interior

$1974 $116/night
Price Curve

Oceanview

$2074 $122/night
Price Curve

Balcony

$3124 $183/night
Price Curve

Suite

$4974 $292/night
Price Curve

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-12%

4 Night South America
MSC Lirica
2.9 "Nice"

PORTS

Santos (Sao Paolo) Brazil; Buzios, Brazil; Ilha Grande, Brazil; Santos (Sao Paolo) Brazil

SAIL DATE:   Dec 08, 2025   -   Dec 12, 2025

Interior

$379 $94/night
Price Curve

Oceanview

$489 $122/night
Price Curve

Balcony

$709 $177/night
Price Curve

Suite

$899 $224/night
Price Curve

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Very good price

Compared to other cruises

7 Night South America
MSC Lirica
2.9 "Nice"

PORTS

Piraeus; Izmir (Ephesus) Turkey; Istanbul; Corfu; Bari, Italy; Piraeus

SAIL DATE:   Dec 15, 2025   -   Dec 22, 2025

Interior

$675 $96/night
Price Curve

Oceanview

$815 $116/night
Price Curve

Balcony

$1105 $157/night
Price Curve

Suite

$1305 $186/night
Price Curve

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-6%

31 Night South America
Oosterdam
4.0 "Good"

PORTS

Fort Lauderdale; George Town, Cayman Islands; Fuerte Amador, Panama; Fuerte Amador, Pana... Buenos Aires

SAIL DATE:   Nov 18, 2026   -   Dec 19, 2026

Interior

$3889 $125/night
Price Curve

Oceanview

$4339 $139/night
Price Curve

Balcony

$5909 $190/night
Price Curve

Suite

$8519 $274/night
Price Curve

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7 Night South America
MSC Sinfonia
3.3 "Good"

PORTS

Itajai Brazil; Santos (Sao Paulo), Brazil; Ilha Grande, Brazil; Rio de Janeiro; Buzios,... Itajai Brazil

SAIL DATE:   Jan 04, 2026   -   Jan 11, 2026

Interior

$778 $111/night
Price Curve

Oceanview

$949 $135/night
Price Curve

Balcony

$1349 $192/night
Price Curve

Suite

$1689 $241/night
Price Curve

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-7%

7 Night South America
MSC Sinfonia
3.3 "Good"

PORTS

Itajai Brazil; Santos (Sao Paulo), Brazil; Ilha Grande, Brazil; Rio de Janeiro; Buzios... Itajai Brazil

SAIL DATE:   Jan 18, 2026   -   Jan 25, 2026

Interior

$778 $111/night
Price Curve

Oceanview

$949 $135/night
Price Curve

Balcony

$1349 $192/night
Price Curve

Suite

$1689 $241/night
Price Curve

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With cruisewatch.com, it’s easier than ever to find the best South America cruises for the best price. We use data-driven analytics to simplify the process - from finding the sailing that’s perfect for you to offering unmatched price prediction to let you know when to book. Our personalized and super-refined search engine also gives you complete control, and with free automatic price alerts, staying on top of the market is stress-free. Take advantage of our awesome features to save up to 70% off your dream South America cruise and explore our library of free resources and expert insights so you can make your South America cruise truly unforgettable!