Best Cruises from San Diego
We've found the Best Cruises from San Diego for the best prices! Easily compare sailings and find out when to book with our unique cruise search.
15 Night Panama Canal
PORTS
San Diego; Cabo San Lucas; Acapulco; Puerto Quetzal, Guatemala; Puntarenas Puerto Cal... Miami, Florida
SAIL DATE: Feb 12, 2026 - Feb 27, 2026
26 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Puer... Miami, Florida
SAIL DATE: Feb 27, 2026 - Mar 25, 2026
11 Night Mexico
PORTS
San Diego; Cabo San Lucas; Mazatlan; Puerto Vallarta; San Diego; Avalon, Catalina Island, C... Vancouver
SAIL DATE: Apr 25, 2026 - May 06, 2026
Interior
$1064 $96/night
Oceanview
$1214 $110/night
Balcony
not available
Suite
$2764 $251/night
15 Night Panama Canal
PORTS
San Diego; Cabo San Lucas; Acapulco; Puerto Quetzal, Guatemala; Puntarenas Puerto Cal... Miami, Florida
SAIL DATE: Apr 03, 2027 - Apr 18, 2027
14 Night Panama Canal
PORTS
San Diego; Cabo San Lucas; Acapulco; Puerto Quetzal, Guatemala; Panama City (Pct), Pan... Miami, Florida
SAIL DATE: Oct 18, 2025 - Nov 01, 2025
15 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Puer... Miami, Florida
SAIL DATE: Feb 27, 2026 - Mar 14, 2026
11 Night Mexico
PORTS
San Diego; Cabo San Lucas; PICHILINGUE (LA PAZ); Loreto, Mexico; Mazatlan; Puerto Vallarta;... San Diego
SAIL DATE: Apr 07, 2026 - Apr 18, 2026
Interior
$1184 $107/night
Oceanview
$1334 $121/night
Balcony
not available
Suite
$2884 $262/night
14 Night Mexico
PORTS
San Diego; Cabo San Lucas; PICHILINGUE (LA PAZ); Loreto, Mexico; San Diego; Cabo San Lucas;... San Diego
SAIL DATE: Apr 18, 2026 - May 02, 2026
Interior
$1519 $108/night
Oceanview
$1699 $121/night
Balcony
not available
Suite
$3769 $269/night
30 Night Hawaii
PORTS
San Diego; Nawiliwili, Kauai; Honolulu; Honolulu; Hilo; Kona, Hawaii, Us; Kahului, Maui; En... San Diego
SAIL DATE: Nov 19, 2026 - Dec 19, 2026
Interior
$3289 $109/night
Oceanview
$3939 $131/night
Balcony
not available
Suite
$8089 $269/night
12 Night Mexico
PORTS
San Diego; Cabo San Lucas; PICHILINGUE (LA PAZ); Loreto, Mexico; Guaymas, Mexico; Topolobam... San Diego
SAIL DATE: Feb 15, 2026 - Feb 27, 2026
