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San Diego Two Stars 250 $ to 350 $
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Best Cruises from San Diego

We've found the Best Cruises from San Diego for the best prices! Easily compare sailings and find out when to book with our unique cruise search.

Very good price

Compared to other cruises

7 Night Mexico
Serenade of the Seas
4.0 "Good"

PORTS

San Diego; La Paz; Cabo San Lucas; Ensenada; San Diego

SAIL DATE:   Jan 03, 2027   -   Jan 10, 2027

Interior

$531 $75/night
Price Curve

Oceanview

$732 $104/night
Price Curve

Balcony

$849 $121/night
Price Curve

Suite

$1859 $265/night
Price Curve

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Very good price

Compared to other cruises

7 Night Mexico
Serenade of the Seas
4.0 "Good"

PORTS

San Diego; Ensenada; Cabo San Lucas; Mazatlan; San Diego

SAIL DATE:   Nov 08, 2026   -   Nov 15, 2026

Interior

$542 $77/night
Price Curve

Oceanview

$741 $105/night
Price Curve

Balcony

$924 $132/night
Price Curve

Suite

$1939 $277/night
Price Curve

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Very good price

Compared to other cruises

7 Night Mexico
Serenade of the Seas
4.0 "Good"

PORTS

San Diego; Cabo San Lucas; Mazatlan; La Paz; San Diego

SAIL DATE:   Jan 28, 2027   -   Feb 04, 2027

Interior

$549 $78/night
Price Curve

Oceanview

$759 $108/night
Price Curve

Balcony

$869 $124/night
Price Curve

Suite

$2099 $299/night
Price Curve

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Very good price

Compared to other cruises

14 Night Mexico
Nieuw Amsterdam
3.9 "Good"

PORTS

San Diego; Cabo San Lucas; PICHILINGUE (LA PAZ); Loreto, Mexico; San Diego; Avalon, Catalin... San Diego

SAIL DATE:   Oct 25, 2025   -   Nov 08, 2025

Interior

$1124 $80/night
Price Curve

Oceanview

$1254 $89/night
Price Curve

Balcony

$1684 $120/night
Price Curve

Suite

$3594 $256/night
Price Curve

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Very good price

Compared to other cruises

7 Night Pacific Coastal
Nieuw Amsterdam
3.9 "Good"

PORTS

San Diego; Avalon, Catalina Island, California; San Francisco; San Francisco; Ensenada; San Diego

SAIL DATE:   Nov 01, 2025   -   Nov 08, 2025

Interior

$574 $82/night
Price Curve

Oceanview

$674 $96/night
Price Curve

Balcony

$874 $124/night
Price Curve

Suite

$2174 $310/night
Price Curve

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Very good price

Compared to other cruises

7 Night Mexico
Serenade of the Seas
4.0 "Good"

PORTS

San Diego; Ensenada; Cabo San Lucas; Mazatlan; San Diego

SAIL DATE:   Nov 01, 2026   -   Nov 08, 2026

Interior

$561 $80/night
Price Curve

Oceanview

$741 $105/night
Price Curve

Balcony

$944 $134/night
Price Curve

Suite

$1999 $285/night
Price Curve

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Very good price

Compared to other cruises

14 Night Mexico
Nieuw Amsterdam
3.9 "Good"

PORTS

San Diego; Ensenada; San Francisco; San Francisco; Santa Barbara, California; San Diego; Pu... San Diego

SAIL DATE:   Oct 11, 2025   -   Oct 25, 2025

Interior

$1159 $82/night
Price Curve

Oceanview

$1289 $92/night
Price Curve

Balcony

$1759 $125/night
Price Curve

Suite

$3669 $262/night
Price Curve

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Very good price

Compared to other cruises

7 Night Mexico
Serenade of the Seas
4.0 "Good"

PORTS

San Diego; Ensenada; Cabo San Lucas; La Paz; San Diego

SAIL DATE:   Nov 15, 2026   -   Nov 22, 2026

Interior

$561 $80/night
Price Curve

Oceanview

$741 $105/night
Price Curve

Balcony

$944 $134/night
Price Curve

Suite

$1949 $278/night
Price Curve

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Very good price

Compared to other cruises

7 Night Mexico
Serenade of the Seas
4.0 "Good"

PORTS

San Diego; Catalina Island; Ensenada; Cabo San Lucas; Cabo San Lucas; San Diego

SAIL DATE:   Dec 13, 2026   -   Dec 20, 2026

Interior

$561 $80/night
Price Curve

Oceanview

$741 $105/night
Price Curve

Balcony

$944 $134/night
Price Curve

Suite

$1839 $262/night
Price Curve

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Very good price

Compared to other cruises

14 Night Mexico
Nieuw Amsterdam
3.9 "Good"

PORTS

San Diego; Ensenada; Cabo San Lucas; Puerto Vallarta; San Diego; Ensenada; San Francisco; S... San Diego

SAIL DATE:   Oct 04, 2025   -   Oct 18, 2025

Interior

$1199 $85/night
Price Curve

Oceanview

$1369 $97/night
Price Curve

Balcony

$1839 $131/night
Price Curve

Suite

$3659 $261/night
Price Curve

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Discover the best cruises from San Diego with our ultra-refined cruise search. Plus, save up to 70% off when you use our unmatched price prediction and free automatic price alerts! With cruisewatch.com, it’s simpler than ever to find your perfect cruise from San Diego and make it a vacation to remember. Explore expert tips and advice for all cruise lines, destinations, and cruise styles and set sail for savings from San Diego! Pack your bags and get ready to go - your dream cruise is now closer and better than ever!