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Best Cruises from San Diego

We've found the Best Cruises from San Diego for the best prices! Easily compare sailings and find out when to book with our unique cruise search.

Very good price

Compared to other cruises

13 Night Panama Canal
Serenade of the Seas
4.0 "Good"

PORTS

San Diego; Puerto Vallarta; Huatulco, Mexico; Puntarenas, Costa Rica; Cartagena, Spain; Miami, Florida

SAIL DATE:   Sep 19, 2025   -   Oct 02, 2025

Interior

$991 $76/night
Price Curve

Oceanview

$1411 $108/night
Price Curve

Balcony

not available
Price Curve

Suite

not available
Price Curve

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Very good price

Compared to other cruises

28 Night Panama Canal
Koningsdam
3.9 "Good"

PORTS

San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale

SAIL DATE:   Nov 01, 2025   -   Nov 29, 2025

Interior

$2409 $86/night
Price Curve

Oceanview

$3119 $111/night
Price Curve

Balcony

$3969 $141/night
Price Curve

Suite

$6109 $218/night
Price Curve

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Very good price

Compared to other cruises

17 Night Panama Canal
Koningsdam
3.9 "Good"

PORTS

San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale

SAIL DATE:   Nov 01, 2025   -   Nov 18, 2025

Interior

$1524 $89/night
Price Curve

Oceanview

$2024 $119/night
Price Curve

Balcony

$2669 $157/night
Price Curve

Suite

$4119 $242/night
Price Curve

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Very good price

Compared to other cruises

16 Night Panama Canal
Island Princess
3.9 "Good"

PORTS

San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mex... Ft. Lauderdale, Florida

SAIL DATE:   Jan 29, 2027   -   Feb 14, 2027

Interior

$1386 $86/night
Price Curve

Oceanview

$1546 $96/night
Price Curve

Balcony

$2571 $160/night
Price Curve

Suite

$3096 $193/night
Price Curve

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Very good price

Compared to other cruises

24 Night Panama Canal
Eurodam
4.0 "Good"

PORTS

San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale

SAIL DATE:   Oct 09, 2025   -   Nov 02, 2025

Interior

$2474 $103/night
Price Curve

Oceanview

$2564 $106/night
Price Curve

Balcony

$3834 $159/night
Price Curve

Suite

$7804 $325/night
Price Curve

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Very good price

Compared to other cruises

17 Night Panama Canal
Eurodam
4.0 "Good"

PORTS

San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale

SAIL DATE:   Oct 09, 2025   -   Oct 26, 2025

Interior

$1804 $106/night
Price Curve

Oceanview

$1854 $109/night
Price Curve

Balcony

$3084 $181/night
Price Curve

Suite

$7874 $463/night
Price Curve

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15 Night Panama Canal
Norwegian Jade
3.5 "Good"

PORTS

San Diego; Cabo San Lucas; Acapulco; Puerto Quetzal, Guatemala; Puntarenas Puerto Cal... Miami, Florida

SAIL DATE:   Feb 12, 2026   -   Feb 27, 2026

Interior

$1409 $93/night
Price Curve

Oceanview

$1799 $119/night
Price Curve

Balcony

$3899 $259/night
Price Curve

Suite

$4299 $286/night
Price Curve

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Very good price

Compared to other cruises

26 Night Panama Canal
Zuiderdam
3.9 "Good"

PORTS

San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Puer... Miami, Florida

SAIL DATE:   Feb 27, 2026   -   Mar 25, 2026

Interior

$2719 $104/night
Price Curve

Oceanview

$2989 $114/night
Price Curve

Balcony

$4549 $174/night
Price Curve

Suite

$6829 $262/night
Price Curve

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27 Night Panama Canal
Zuiderdam
3.9 "Good"

PORTS

San Diego; Cabo San Lucas; PICHILINGUE (LA PAZ); Loreto, Mexico; Guaymas, Mexico; Topo... Miami, Florida

SAIL DATE:   Feb 15, 2026   -   Mar 14, 2026

Interior

$2939 $108/night
Price Curve

Oceanview

$3209 $118/night
Price Curve

Balcony

$4969 $184/night
Price Curve

Suite

not available
Price Curve

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15 Night Panama Canal
Norwegian Star
3.5 "Good"

PORTS

San Diego; Cabo San Lucas; Acapulco; Puerto Quetzal, Guatemala; Puntarenas Puerto Cal... Miami, Florida

SAIL DATE:   Apr 03, 2027   -   Apr 18, 2027

Interior

$1549 $103/night
Price Curve

Oceanview

$2049 $136/night
Price Curve

Balcony

$3199 $213/night
Price Curve

Suite

$3849 $256/night
Price Curve

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Discover the best cruises from San Diego with our ultra-refined cruise search. Plus, save up to 70% off when you use our unmatched price prediction and free automatic price alerts! With cruisewatch.com, it’s simpler than ever to find your perfect cruise from San Diego and make it a vacation to remember. Explore expert tips and advice for all cruise lines, destinations, and cruise styles and set sail for savings from San Diego! Pack your bags and get ready to go - your dream cruise is now closer and better than ever!