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San Diego Holland America Line 250 $ to 350 $
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Best Cruises from San Diego

We've found the Best Cruises from San Diego for the best prices! Easily compare sailings and find out when to book with our unique cruise search.

Very good price

Compared to other cruises

14 Night Mexico
Nieuw Amsterdam
3.9 "Good"

PORTS

San Diego; Avalon, Catalina Island, California; San Francisco; San Francisco; Ensenada; San... San Diego

SAIL DATE:   Nov 01, 2025   -   Nov 15, 2025

Interior

$1224 $87/night
Price Curve

Oceanview

$1354 $96/night
Price Curve

Balcony

$1734 $123/night
Price Curve

Suite

$4074 $291/night
Price Curve

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Very good price

Compared to other cruises

17 Night Panama Canal
Koningsdam
3.9 "Good"

PORTS

San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale

SAIL DATE:   Nov 01, 2025   -   Nov 18, 2025

Interior

$1624 $95/night
Price Curve

Oceanview

$2124 $124/night
Price Curve

Balcony

$2819 $165/night
Price Curve

Suite

$4319 $254/night
Price Curve

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Very good price

Compared to other cruises

14 Night Mexico
Nieuw Amsterdam
3.9 "Good"

PORTS

San Diego; Puerto Vallarta; Mazatlan; Cabo San Lucas; San Diego; Cabo San Lucas; PICHILINGU... San Diego

SAIL DATE:   Nov 08, 2025   -   Nov 22, 2025

Interior

$1314 $93/night
Price Curve

Oceanview

$1354 $96/night
Price Curve

Balcony

$1824 $130/night
Price Curve

Suite

$3534 $252/night
Price Curve

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Very good price

Compared to other cruises

14 Night Mexico
Nieuw Amsterdam
3.9 "Good"

PORTS

San Diego; Cabo San Lucas; PICHILINGUE (LA PAZ); Loreto, Mexico; San Diego; Avalon, Catalin... San Diego

SAIL DATE:   Oct 25, 2025   -   Nov 08, 2025

Interior

$1314 $93/night
Price Curve

Oceanview

$1404 $100/night
Price Curve

Balcony

$1824 $130/night
Price Curve

Suite

$4164 $297/night
Price Curve

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Very good price

Compared to other cruises

10 Night Mexico
Nieuw Amsterdam
3.9 "Good"

PORTS

San Diego; Cabo San Lucas; PICHILINGUE (LA PAZ); Loreto, Mexico; Mazatlan; Puerto Vallarta; San Diego

SAIL DATE:   Nov 29, 2025   -   Dec 09, 2025

Interior

$964 $96/night
Price Curve

Oceanview

$1014 $101/night
Price Curve

Balcony

$1364 $136/night
Price Curve

Suite

$2964 $296/night
Price Curve

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Very good price

Compared to other cruises

11 Night Mexico
Nieuw Amsterdam
3.9 "Good"

PORTS

San Diego; Puerto Vallarta; Manzanillo; Mazatlan; Loreto, Mexico; PICHILINGUE (LA PAZ); Cab... San Diego

SAIL DATE:   Dec 09, 2025   -   Dec 20, 2025

Interior

$1064 $96/night
Price Curve

Oceanview

$1114 $101/night
Price Curve

Balcony

$1464 $133/night
Price Curve

Suite

$3064 $278/night
Price Curve

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Very good price

Compared to other cruises

24 Night Panama Canal
Eurodam
4.0 "Good"

PORTS

San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale

SAIL DATE:   Oct 09, 2025   -   Nov 02, 2025

Interior

$2574 $107/night
Price Curve

Oceanview

$2664 $111/night
Price Curve

Balcony

$4084 $170/night
Price Curve

Suite

$7814 $325/night
Price Curve

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Very good price

Compared to other cruises

14 Night Mexico
Nieuw Amsterdam
3.9 "Good"

PORTS

San Diego; Puerto Vallarta; Mazatlan; Cabo San Lucas; San Diego; Cabo San Lucas; PICHILINGU... San Diego

SAIL DATE:   Oct 18, 2025   -   Nov 01, 2025

Interior

$1444 $103/night
Price Curve

Oceanview

$1444 $103/night
Price Curve

Balcony

$1994 $142/night
Price Curve

Suite

$3704 $264/night
Price Curve

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Very good price

Compared to other cruises

7 Night Mexico
Nieuw Amsterdam
3.9 "Good"

PORTS

San Diego; Puerto Vallarta; Mazatlan; Cabo San Lucas; San Diego

SAIL DATE:   Nov 08, 2025   -   Nov 15, 2025

Interior

$729 $104/night
Price Curve

Oceanview

$779 $111/night
Price Curve

Balcony

$1079 $154/night
Price Curve

Suite

$2229 $318/night
Price Curve

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4 Night Pacific Coastal
Koningsdam
3.9 "Good"

PORTS

San Diego; Victoria; Vancouver

SAIL DATE:   Apr 03, 2027   -   Apr 07, 2027

Interior

$439 $109/night
Price Curve

Oceanview

$589 $147/night
Price Curve

Balcony

$689 $172/night
Price Curve

Suite

$1089 $272/night
Price Curve

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Discover the best cruises from San Diego with our ultra-refined cruise search. Plus, save up to 70% off when you use our unmatched price prediction and free automatic price alerts! With cruisewatch.com, it’s simpler than ever to find your perfect cruise from San Diego and make it a vacation to remember. Explore expert tips and advice for all cruise lines, destinations, and cruise styles and set sail for savings from San Diego! Pack your bags and get ready to go - your dream cruise is now closer and better than ever!