Best Cruises from San Diego
We've found the Best Cruises from San Diego for the best prices! Easily compare sailings and find out when to book with our unique cruise search.
17 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale
SAIL DATE: Nov 01, 2025 - Nov 18, 2025
4 Night Pacific Coastal
PORTS
San Diego; Avalon, Catalina Island, California; Vancouver
SAIL DATE: Apr 20, 2026 - Apr 24, 2026
24 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale
SAIL DATE: Oct 09, 2025 - Nov 02, 2025
7 Night Mexico
PORTS
San Diego; Puerto Vallarta; Mazatlan; Cabo San Lucas; San Diego
SAIL DATE: Nov 08, 2025 - Nov 15, 2025
11 Night Mexico
PORTS
San Diego; Manzanillo; Puerto Vallarta; Mazatlan; PICHILINGUE (LA PAZ); Loreto, Mexico; Cab... San Diego
SAIL DATE: Dec 08, 2026 - Dec 19, 2026
14 Night Mexico
PORTS
San Diego; Ensenada; Cabo San Lucas; Puerto Vallarta; San Diego; Ensenada; San Francisco; S... San Diego
SAIL DATE: Oct 04, 2025 - Oct 18, 2025
Interior
$1549 $110/night
Oceanview
$1639 $117/night
Balcony
$2109 $150/night
Suite
not available
10 Night Mexico
PORTS
San Diego; Cabo San Lucas; PICHILINGUE (LA PAZ); Loreto, Mexico; Mazatlan; Puerto Vallarta; San Diego
SAIL DATE: Nov 28, 2026 - Dec 08, 2026
14 Night Mexico
PORTS
San Diego; Puerto Vallarta; Mazatlan; Cabo San Lucas; San Diego; Cabo San Lucas; PICHILINGU... San Diego
SAIL DATE: Mar 21, 2026 - Apr 04, 2026
7 Night Mexico
PORTS
San Diego; Cabo San Lucas; PICHILINGUE (LA PAZ); Loreto, Mexico; San Diego
SAIL DATE: Oct 25, 2025 - Nov 01, 2025
