Best Cruises from San Diego
We've found the Best Cruises from San Diego for the best prices! Easily compare sailings and find out when to book with our unique cruise search.
28 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale
SAIL DATE: Nov 01, 2025 - Nov 29, 2025
17 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale
SAIL DATE: Nov 01, 2025 - Nov 18, 2025
24 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale
SAIL DATE: Oct 09, 2025 - Nov 02, 2025
17 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale
SAIL DATE: Oct 09, 2025 - Oct 26, 2025
16 Night Panama Canal
PORTS
San Diego; Cabo San Lucas; Acapulco; Huatulco, Mexico; Puerto Chiapas (Tapachula), Me... Fort Lauderdale
SAIL DATE: Oct 08, 2026 - Oct 24, 2026
16 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale
SAIL DATE: Oct 02, 2026 - Oct 18, 2026
15 Night Hawaii
PORTS
San Diego; Cabo San Lucas; Puerto Vallarta; Huatulco, Mexico; Puerto Quetzal, Guatema... Fort Lauderdale
SAIL DATE: Dec 19, 2026 - Jan 03, 2027
Interior
$2764 $184/night
Oceanview
$3064 $204/night
Balcony
not available
Suite
$4964 $330/night
14 Night World Cruise
PORTS
San Diego; Manzanillo; Puerto Chiapas (Tapachula), Mexico; Acajutla, El Salvador; Fue... Fort Lauderdale
SAIL DATE: May 03, 2026 - May 17, 2026
Interior
$3709 $264/night
Oceanview
$3999 $285/night
Balcony
not available
Suite
$6789 $484/night