Best Cruises from San Diego
We've found the Best Cruises from San Diego for the best prices! Easily compare sailings and find out when to book with our unique cruise search.
16 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mex... Ft. Lauderdale, Florida
SAIL DATE: Jan 29, 2027 - Feb 14, 2027
17 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale
SAIL DATE: Nov 01, 2025 - Nov 18, 2025
15 Night Panama Canal
PORTS
San Diego; Cabo San Lucas; Acapulco; Puerto Quetzal, Guatemala; Puntarenas Puerto Cal... Miami, Florida
SAIL DATE: Feb 12, 2026 - Feb 27, 2026
17 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale
SAIL DATE: Oct 09, 2025 - Oct 26, 2025
15 Night Panama Canal
PORTS
San Diego; Cabo San Lucas; Acapulco; Puerto Quetzal, Guatemala; Puntarenas Puerto Cal... Miami, Florida
SAIL DATE: Apr 03, 2027 - Apr 18, 2027
15 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Puer... Miami, Florida
SAIL DATE: Feb 27, 2026 - Mar 14, 2026
16 Night Panama Canal
PORTS
San Diego; Cabo San Lucas; Acapulco; Huatulco, Mexico; Puerto Chiapas (Tapachula), Me... Fort Lauderdale
SAIL DATE: Oct 08, 2026 - Oct 24, 2026
16 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Pue... Fort Lauderdale
SAIL DATE: Oct 02, 2026 - Oct 18, 2026
16 Night Panama Canal
PORTS
San Diego; Cabo San Lucas; Mazatlan; Puerto Quetzal, Guatemala; Puntarenas, Costa Ric... Fort Lauderdale
SAIL DATE: Oct 04, 2025 - Oct 20, 2025
Interior
$2916 $182/night
Oceanview
not available
Balcony
not available
Suite
not available
15 Night Panama Canal
PORTS
San Diego; Puerto Vallarta; Huatulco, Mexico; Puerto Chiapas (Tapachula), Mexico; Puer... Miami, Florida
SAIL DATE: Jan 30, 2027 - Feb 14, 2027
